Syndrome de Lyell ou de Stevens-Johnson

Juste parce qu'en cherchant des informations sur l'AVC j'ai trouvé l'histoire d'une chienne souffrant de ce syndrome.

Je vous conseille de ne pas chercher d'infos et surtout pas d'images!!!!!! pale

Syndrome de Lyell ou de Stevens-Johnson Chien_22

Citation :: Le syndrome de Lyell1 (ou nécrolyse épidermique toxique) est un état dermatologique potentiellement létal et induit en général par un médicament, entrainant une réaction du système immunitaire mal comprise et aboutissant à la nécrose des kératinocytes (cellules de la peau) comme dans une brûlure thermique ou chimique. Il tire son nom du dermatologue écossais Alan Lyell (4 novembre 1917 – 2 novembre 2007).

Le syndrome de Lyell est une affection apparentée au syndrome de Stevens-Johnson et à l'érythème polymorphe. C'est une dermatose bulleuse définie par une nécrose épidermique, atteignant plus de 30 % de la surface corporelle.
Il se manifeste par des signes généraux : fièvre, dysphagie, sensations de brûlures oculaires. Des bulles et des décollements épidermiques surviennent dans les 1 à 2 jours. Une atteinte des muqueuses respiratoires, digestives, buccales et/ou vaginales sont presque toujours associées.

Il est d'origine exclusivement médicamenteuse, survenant 7 à 21 jours après le début de la prise médicamenteuse. Les médicaments les plus souvent impliqués sont les antibiotiques sulfamidés, antiépileptiques et AINS. Ainsi que la Viramune ou Névirapine, (Antirétroviral). Le syndrome de Lyell est plus fréquent chez les femmes que chez les hommes. La plus grande incidence chez les personnes âgées est probablement due au plus grand nombre de médicaments qui leur sont prescrits[réf. nécessaire].

Le diagnostic nécessite une hospitalisation d'urgence en raison d'une mortalité élevée (20 à 70 % suivant les études) par insuffisance rénale, défaillance cardiaque ou complications similaires à celles des grands brulés (pertes protéiques, infections).

Diagnostic différentiel : syndrome d'épidermolyse staphylococcique aiguë, survenant surtout chez les enfants, par production d'une toxine épidermolytique produit par certains staphylocoques.

http://fr.wikipedia.org/wiki/Syndrome_de_Lyell

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Syndrome de Lyell ou de Stevens-Johnson Bt_sig10

Quand on cherche avec les termes "Idiopathic Epidermal Necrolysis Syndrome - IENS"

Citation :: Toxic Epidermal Necrolysis

Toxic epidermal necrolysis is a rare, ulcerative skin disease that appears to be triggered by various drugs, internal cancers, infections, and unknown factors.

Symptoms

Blebs (an irregular bulge in the plasma membrane of a cell), ulcers, and erosions develop suddenly and progress rapidly. The mouth and foot pads are frequently involved. This is an extremely painful disease. The dog is severely depressed and refuses to eat. The fatality rate approaches 30%

All symptoms +

Causes

This condition appears to be triggered by various drugs, internal cancers, infections, and unknown factors.

Diagnosis

Diagnosis is made by physical examination.
Treatment

Treatment involves stopping all suspect medications and correcting and underlying cause. Corticosteroids, intravenous fluids, and antibiotics are required during the acute phase of the illness to support the circulation. Recovery takes 2 - 3 weeks.
Prevention

There is currently no known prevention for this condition.

http://www.wiki-pet.com/health/dog/condition/index.php?condition_id=99

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Syndrome de Lyell ou de Stevens-Johnson Bt_sig10

Ça fait peur pale

...
Franchement rien qu'en, lisant le descriptif, on n'a pas pas envie de chercher sur google !
Tout de même, c'est bon à savoir, merci.

En cherchant avec les termes "Toxic epidermal necrolysis dog"

Citation :: Toxic Epidermal Necrolysis in Dogs

Understanding the symptoms of toxic epidermal necrolysis (TEN) allows you to seek immediate care. Few dogs survive this deadly disease. Because of this, early treatment provides the best odds for your dog's recovery. Your dog's survival rate is dictated by infections. The earlier your dog is contained in a sterile environment, the better the dog's chances of beating the disease.
Understanding What TEN Involves

With TEN, the outer layer of the skin separates from the remaining skin layers. It's appearance is similar to severe burns and treatments are similar. On average, 90 percent of all cases of toxic epidermal necrolysis appear following an allergic reaction to a new medication. The disease may also occur with certain cancers. Staph infections share a similar appearance, so your veterinarian will want to make sure a staph infection is not present.

TEN is a rare disease affecting many mammals including cats, dogs, humans and monkeys. The biggest danger with open sores is the risk of infection. It is not advised to try to treat TEN at home. A sterile environment is important. Prognosis for those inflicted with TEN is not great. Studies find that humans afflicted with TEN have a 50/50 chance of survival, dogs odds are lower than that because pet owners tend to delay treatment thinking it's a rash or bad insect bite.
Symptoms of Canine Toxic Epidermal Necrolysis

TEN starts with a high fever. There may be a cough and usually the dog will become lethargic and unwilling to eat. As the disease progresses, the skin and mucus membranes, such as the mouth and nose, form large blisters. When these blisters rupture, the turn into ulcers, sometimes bloody and a purplish-red color.

Left untreated, canine toxic epidermal necrolysis can lead to death, mostly due to infections. But, dehydration from leaking body fluids from the ulcers can cause an electrolyte imbalance. As the body loses valuable electrolytes, the heart and kidneys are affected. Heart and kidney failure are other reasons dogs with TEN succumb to the illness.
How Vets Diagnose TEN

Upon seeing your dog, it's likely that your vet will ask if the dog has taken any new medications in the past three weeks. Next, he will take a tissue sample for a biopsy. The biopsy will help determine if there is a staph infection or if blisters are the result of TEN.
Treatment Options for Canine Toxic Epidermal Necrolysis

If your dog is diagnosed with canine TEN, he will be moved to a sterile kennel, usually in an animal hospital that is equipped to treat burn patients.

IV fluids will be used to replace any fluid and electrolyte imbalances. Veterinarians prescribe antibiotics to help battle and ward off infections. The lesions may be treated with a topical disinfectant to prevent infection. If the lesions are large, some veterinarians prefer to keep them covered with skin grafts to aid in healing. Keeping the lesions covered also protects from infection

Some veterinarians use anti-inflammatory medications to relieve pain and swelling. These medications are not always effective and affect immune system function, so discuss the advantages and disadvantages before using them.

http://www.vetinfo.com/toxic-epidermal-necrolysis-in-dogs.html

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Syndrome de Lyell ou de Stevens-Johnson Bt_sig10

Citation :: Canine Toxic Epidermal Necrolysis

Toxic epidermal necrolysis (TEN) is a life-threatening ulcerative skin disease that involves the mucous membranes and skin surfaces and causes tissue death (necrosis). Necrosis of the mucosa of the trachea, large bronchi, pharynx and esophagus can also occur. What causes the disease is unknown. In dogs, the disease is often associated with some predisposing conditions, such as staphylococcal infection, drug administration, cancers, and metabolic disorders. The disease is marked by large, painful, ulcerative areas on any part of the body, but particularly on the head, footpads, and mucocutaneous junctions (transitional zones between the skin and mucous membranes in the mouth, nose, etc.). Toxic epidermal necrolysis can mimic a massive second-degree burn. The necrotic outer layer of the skin (epidermis) separates from the dermis to form variably sized blisters, which rupture, forming ulcers. Ulceration often induces a secondary dermatitis. Fever, loss of appetite, shock, and even death may be a consequence of TEN.

The diagnosis is based on history, clinical signs and skin biopsy. Biopsy of red, non-ulcerated areas reveals acute necrosis of the entire thickness of the epidermis and the formation of subepidermal blisters (vesicles). Additional tests may be required to include a hemogram, serum chemistry profile and analysis of the urine. Common abnormalities include increase in the number of white blood cells (leukocytosis), electrolyte abnormalities that can cause heart failure, low level of total serum protein (hypoproteinemia), and abnormal kidney function. Supportive topical therapy with astringents (remedies that have a 'binding' action on tissue), intravenous fluid therapy, and systemic antibiotics usually is indicated. Corticosteroids use in the treatment of TEN is controversial. The underlying disease must be identified and treated if TEN is to resolve. The prognosis is poor as toxic epidermal necrolysis has a high mortality rate due to fluid and electrolyte loss through the damaged skin.
References

Nesbitt G.E. & Ackerman L.J. Canine Immune-Mediated Skin Diseases. In: Canine and Feline Dermatology: Diagnosis and Treatment. Veterinary Learning Systems, Trenton, New Jersey
Results AFIP Wednesday Slide Conference - No. 27 8 May 1996, Division of Comparative Pathology, John Hopkins University, MD

http://www.gopetsamerica.com/dog-health/toxic_epidermal_necrolysis.aspx

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Syndrome de Lyell ou de Stevens-Johnson Bt_sig10

Et enfin, l'histoire de Justine, le Colley...

http://marineetlesanimaux.blog2b.net/

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Syndrome de Lyell ou de Stevens-Johnson Bt_sig10

Petitblue a écrit:: Ça fait peur ...
Franchement rien qu'en, lisant le descriptif, on n'a pas pas envie de chercher sur google !
Tout de même, c'est bon à savoir, merci.

Oui, oui, abstenez-vous de chercher!

Je n'ai pas trouvé d'autres témoignages que celui concernant Justine...

C'est étonnant mais tant mieux si y a pas plus de cas!

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Syndrome de Lyell ou de Stevens-Johnson Bt_sig10

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